Mechanisms of Gene Regulation: How Science Works by Carsten Carlberg & Ferdinand Molnár
Author:Carsten Carlberg & Ferdinand Molnár
Language: eng
Format: epub
ISBN: 9783030523213
Publisher: Springer International Publishing
The key epigenomic methods determine DNA methylation, transcription factor binding and histone modification, accessible chromatin and 3D chromatin architecture. The biochemical cores of these methods aredifferent chemical susceptibility of nucleotides, such as bisulfite treatment of genomic DNA, in order to distinguish between cytosine and 5-methylcytosine (5mC)
affinity of specific antibodies for chromatin-associated proteins, such as transcription factors, modified histones and chromatin modifiers
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